Simulation scenario 6

Setting description

Carboplatin more effective in the DRD+ biomarker signature

Simulations setting

PFS distributions

Treatment effects

By subgroup:

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31

By signature:

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.075, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 13.1, median = 9.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1.49, hr = 0.66
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.075, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 13.1, median = 9.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1.49, hr = 0.66
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.075, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 13.1, median = 9.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1.49, hr = 0.66
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.075, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 13.1, median = 9.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1.49, hr = 0.66

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 10 1 16 10 TP53- & AR- 30 31 123 133 TP53+ 5 2 24 27 DRD+ 0 1 267 280 TEfus+ 2 4 31 41

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.020 0.002 0.032 0.020 TP53- & AR- 0.060 0.062 0.246 0.266 TP53+ 0.010 0.004 0.048 0.054 DRD+ 0.000 0.002 0.534 0.560 TEfus+ 0.004 0.008 0.062 0.082

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 17 2 0 0 TP53- & AR- 220 185 8 2 TP53+ 63 63 1 1 DRD+ 78 92 0 0 TEfus+ 59 68 0 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.034 0.004 0.000 0.000 TP53- & AR- 0.440 0.370 0.016 0.004 TP53+ 0.126 0.126 0.002 0.002 DRD+ 0.156 0.184 0.000 0.000 TEfus+ 0.118 0.136 0.000 0.000

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 18 15 11 13 TP53+ 6 14 8 8 DRD+ 0 0 0 0 TEfus+ 0 0 0 2

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.036 0.030 0.022 0.026 TP53+ 0.012 0.028 0.016 0.016 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.000 0.000 0.004

Errors & power

The overall error was 0.372.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.094             0.076             0.136             0.130 

The overall power was 0.786.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.000             0.534             0.560 

Median results at the end of the trial

By signature:

signature	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	graduation	0	10	1	16	10
	futility	0	17	2	0	0
	max_n	0	0	0	0	0
	n	430 (397, 463)	176 (109, 252)	181 (121, 262)	184 (109, 254)	184 (117, 256)
	n_unique	394 (364, 424)	162 (100, 235)	169 (110, 247)	170 (98, 239)	169 (107, 238)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	5 (4, 33)	21 (7, 23)	7 (6, 24)	10 (7, 29)
	post_p	NA (NA, NA)	0.41 (0.06, 0.84)	0.46 (0.08, 0.85)	1 (1, 1)	1 (1, 1)
	rate	0.112 (0.105, 0.12)	0.114 (0.103, 0.129)	0.112 (0.102, 0.126)	0.072 (0.062, 0.084)	0.072 (0.062, 0.085)
TP53- & AR-	graduation	0	30	31	123	133
	futility	0	220	185	8	2
	max_n	0	18	15	11	13
	n	180 (155, 205)	58 (26, 133)	64 (26, 128)	62 (27, 124)	65 (28, 125)
	n_unique	166 (142, 188)	55 (25, 126)	59 (24, 121)	57 (25, 116)	59 (26, 117)
	time_trial	36 (36, 36)	36 (10, 36)	36 (16, 36)	36 (14, 36)	36 (15, 36)
	time_stop	NA (NA, NA)	16 (7, 29)	20 (12, 32)	16 (10, 30)	18 (10, 31)
	post_p	NA (NA, NA)	0.41 (0.06, 0.83)	0.42 (0.08, 0.87)	0.99 (0.81, 1)	0.99 (0.82, 1)
	rate	0.112 (0.101, 0.126)	0.117 (0.097, 0.146)	0.114 (0.097, 0.149)	0.072 (0.053, 0.093)	0.074 (0.052, 0.095)
TP53+	graduation	0	5	2	24	27
	futility	0	63	63	1	1
	max_n	0	6	14	8	8
	n	190 (167, 211)	82 (37, 124)	86 (46, 126)	86 (47, 125)	83 (47, 124)
	n_unique	172 (152, 193)	76 (34, 115)	79 (40, 118)	78 (42, 119)	78 (42, 114)
	time_trial	36 (36, 36)	36 (29, 36)	36 (26, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	22 (9, 32)	19 (10, 32)	13 (9, 22)	16 (10, 32)
	post_p	NA (NA, NA)	0.4 (0.06, 0.84)	0.4 (0.07, 0.87)	0.99 (0.84, 1)	0.99 (0.84, 1)
	rate	0.112 (0.101, 0.124)	0.113 (0.099, 0.141)	0.114 (0.097, 0.138)	0.075 (0.06, 0.093)	0.075 (0.059, 0.093)
DRD+	graduation	0	0	1	267	280
	futility	0	78	92	0	0
	max_n	0	0	0	0	0
	n	118 (101, 135)	34 (19, 63)	36 (24, 63)	67 (27, 102)	65 (27, 103)
	n_unique	107 (90, 123)	30 (17, 56)	32 (22, 57)	62 (25, 95)	60 (25, 96)
	time_trial	36 (36, 36)	36 (31, 36)	36 (28, 36)	34 (12, 36)	32 (12, 36)
	time_stop	NA (NA, NA)	29 (22, 35)	28 (21, 33)	19 (11, 32)	18 (10, 32)
	post_p	NA (NA, NA)	0.36 (0.07, 0.77)	0.36 (0.08, 0.8)	1 (1, 1)	1 (1, 1)
	rate	0.112 (0.098, 0.126)	0.115 (0.092, 0.152)	0.114 (0.09, 0.145)	0.036 (0.029, 0.045)	0.036 (0.028, 0.044)
TEfus+	graduation	0	2	4	31	41
	futility	0	59	68	0	0
	max_n	0	0	0	0	2
	n	157 (139, 177)	63 (31, 91)	72 (40, 101)	70 (37, 105)	68 (40, 103)
	n_unique	143 (126, 161)	57 (29, 84)	67 (37, 92)	64 (34, 98)	63 (37, 95)
	time_trial	36 (36, 36)	36 (30, 36)	36 (27, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	23 (16, 32)	23 (10, 32)	14 (11, 20)	15 (11, 28)
	post_p	NA (NA, NA)	0.4 (0.07, 0.82)	0.39 (0.07, 0.8)	1 (0.94, 1)	1 (0.95, 1)
	rate	0.112 (0.1, 0.125)	0.114 (0.095, 0.144)	0.115 (0.097, 0.136)	0.064 (0.051, 0.082)	0.065 (0.049, 0.079)

By subgroup combinations:

subtype	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	graduation	0	273	217	144	142
	futility	0	0	0	0	0
	max_n	0	18	15	11	13
	n	114 (93, 135)	35 (16, 102)	36 (12, 95)	27 (9, 84)	29 (10, 89)
	n_unique	106 (86, 126)	33 (16, 98)	34 (10, 90)	25 (8, 80)	26 (8, 84)
	post_p	NA (NA, NA)	0.44 (0.1, 0.87)	0.46 (0.1, 0.87)	0.46 (0.1, 0.89)	0.48 (0.08, 0.88)
	rate	0.113 (0.099, 0.131)	0.118 (0.097, 0.159)	0.116 (0.095, 0.175)	0.117 (0.09, 0.186)	0.115 (0.092, 0.179)
—+	graduation	0	294	248	167	167
	futility	0	0	0	0	0
	max_n	0	18	14	11	14
	n	22 (15, 30)	7 (2, 20)	8 (3, 22)	6 (2, 17)	6 (2, 18)
	n_unique	20 (14, 27)	6 (2, 19)	8 (3, 20)	5 (1, 17)	5 (1, 16)
	post_p	NA (NA, NA)	0.43 (0.18, 0.81)	0.44 (0.16, 0.85)	0.47 (0.18, 0.82)	0.44 (0.18, 0.81)
	rate	0.113 (0.081, 0.156)	0.128 (0.08, 0.289)	0.125 (0.081, 0.272)	0.12 (0.072, 0.279)	0.125 (0.071, 0.326)
–+-	graduation	0	90	66	39	37
	futility	0	0	0	0	0
	max_n	0	6	14	8	8
	n	63 (50, 77)	28 (8, 60)	24 (7, 55)	22 (6, 50)	23 (6, 53)
	n_unique	57 (45, 72)	26 (8, 56)	22 (6, 52)	20 (5, 47)	21 (6, 49)
	post_p	NA (NA, NA)	0.45 (0.11, 0.87)	0.41 (0.1, 0.86)	0.44 (0.12, 0.87)	0.45 (0.1, 0.88)
	rate	0.113 (0.093, 0.138)	0.119 (0.092, 0.181)	0.121 (0.091, 0.206)	0.118 (0.09, 0.21)	0.118 (0.089, 0.218)
–++	graduation	0	127	121	63	66
	futility	0	0	0	0	0
	max_n	0	6	13	8	10
	n	42 (33, 53)	16 (4, 37)	21 (7, 43)	15 (4, 35)	13 (4, 33)
	n_unique	39 (30, 49)	15 (4, 35)	19 (6, 40)	14 (3, 33)	12 (3, 31)
	post_p	NA (NA, NA)	0.43 (0.13, 0.84)	0.45 (0.11, 0.87)	0.5 (0.15, 0.85)	0.44 (0.13, 0.84)
	rate	0.112 (0.089, 0.143)	0.121 (0.088, 0.261)	0.119 (0.09, 0.22)	0.115 (0.085, 0.226)	0.124 (0.085, 0.252)
-+–	graduation	0	313	264	332	333
	futility	0	0	0	0	0
	max_n	0	18	15	10	12
	n	21 (14, 29)	4 (0, 13)	5 (2, 14)	10 (3, 22)	10 (3, 22)
	n_unique	19 (13, 26)	4 (0, 12)	5 (2, 13)	9 (3, 21)	9 (3, 21)
	post_p	NA (NA, NA)	0.36 (0.14, 0.66)	0.34 (0.15, 0.66)	0.96 (0.63, 1)	0.95 (0.7, 1)
	rate	0.114 (0.084, 0.151)	0.126 (0.072, 0.406)	0.125 (0.071, 0.34)	0.037 (0.02, 0.07)	0.038 (0.021, 0.067)
-+-+	graduation	0	328	288	337	338
	futility	0	0	0	0	0
	max_n	0	18	14	10	13
	n	21 (15, 28)	4 (0, 13)	5 (1, 14)	10 (3, 23)	10 (3, 23)
	n_unique	19 (13, 26)	3 (0, 12)	4 (1, 13)	9 (3, 22)	9 (3, 21)
	post_p	NA (NA, NA)	0.35 (0.17, 0.65)	0.32 (0.13, 0.67)	0.95 (0.69, 1)	0.96 (0.72, 1)
	rate	0.112 (0.083, 0.151)	0.133 (0.073, 0.405)	0.128 (0.072, 0.365)	0.036 (0.018, 0.066)	0.036 (0.019, 0.066)
-++-	graduation	0	152	149	282	293
	futility	0	0	0	0	0
	max_n	0	6	13	7	7
	n	12 (8, 18)	3 (1, 9)	4 (1, 9)	6 (2, 14)	6 (2, 13)
	n_unique	11 (7, 17)	3 (0, 8)	3 (1, 8)	6 (1, 13)	5 (1, 12)
	post_p	NA (NA, NA)	0.34 (0.16, 0.65)	0.36 (0.18, 0.63)	0.87 (0.5, 0.99)	0.86 (0.5, 0.99)
	rate	0.114 (0.074, 0.175)	0.139 (0.068, 0.51)	0.133 (0.065, 0.474)	0.038 (0.016, 0.095)	0.036 (0.015, 0.1)
-+++	graduation	0	183	190	287	299
	futility	0	0	0	0	0
	max_n	0	6	13	7	9
	n	12 (8, 18)	4 (1, 10)	4 (1, 9)	6 (1, 14)	6 (2, 14)
	n_unique	11 (7, 16)	3 (1, 9)	3 (1, 8)	6 (1, 13)	5 (1, 13)
	post_p	NA (NA, NA)	0.36 (0.18, 0.65)	0.36 (0.17, 0.65)	0.88 (0.49, 0.99)	0.86 (0.49, 0.99)
	rate	0.113 (0.076, 0.171)	0.131 (0.068, 0.426)	0.133 (0.064, 0.351)	0.038 (0.013, 0.099)	0.038 (0.013, 0.094)
+—	graduation	0	27	3	16	10
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	20 (14, 27)	8 (2, 18)	11 (4, 21)	8 (2, 18)	8 (3, 17)
	n_unique	18 (13, 24)	7 (2, 17)	10 (4, 20)	7 (2, 16)	7 (2, 15)
	post_p	NA (NA, NA)	0.42 (0.18, 0.84)	0.49 (0.16, 0.81)	0.47 (0.19, 0.85)	0.46 (0.18, 0.85)
	rate	0.117 (0.085, 0.16)	0.129 (0.078, 0.316)	0.121 (0.082, 0.258)	0.124 (0.073, 0.294)	0.124 (0.072, 0.349)
+–+	graduation	0	84	73	46	46
	futility	0	0	0	0	0
	max_n	0	0	0	0	2
	n	16 (11, 22)	7 (2, 16)	8 (3, 18)	6 (2, 13)	6 (2, 14)
	n_unique	15 (10, 21)	6 (2, 15)	8 (3, 16)	5 (1, 12)	5 (2, 13)
	post_p	NA (NA, NA)	0.43 (0.18, 0.83)	0.44 (0.17, 0.86)	0.45 (0.2, 0.84)	0.48 (0.2, 0.81)
	rate	0.116 (0.079, 0.166)	0.132 (0.075, 0.406)	0.127 (0.073, 0.268)	0.131 (0.071, 0.428)	0.125 (0.068, 0.37)
+-+-	graduation	0	90	66	39	37
	futility	0	0	0	0	0
	max_n	0	6	14	8	8
	n	16 (11, 22)	6 (1, 15)	8 (2, 16)	6 (2, 15)	6 (2, 14)
	n_unique	15 (10, 20)	6 (1, 14)	7 (2, 15)	5 (1, 13)	5 (2, 13)
	post_p	NA (NA, NA)	0.44 (0.2, 0.84)	0.46 (0.18, 0.83)	0.46 (0.2, 0.82)	0.45 (0.19, 0.82)
	rate	0.114 (0.08, 0.167)	0.128 (0.072, 0.361)	0.123 (0.074, 0.328)	0.125 (0.071, 0.388)	0.125 (0.073, 0.371)
+-++	graduation	0	127	121	63	66
	futility	0	0	0	0	0
	max_n	0	6	13	8	10
	n	17 (11, 22)	6 (2, 15)	8 (3, 17)	6 (2, 14)	6 (2, 14)
	n_unique	15 (10, 20)	5 (2, 14)	8 (2, 16)	5 (1, 13)	6 (2, 13)
	post_p	NA (NA, NA)	0.42 (0.19, 0.83)	0.47 (0.19, 0.84)	0.45 (0.2, 0.81)	0.49 (0.22, 0.84)
	rate	0.113 (0.079, 0.167)	0.134 (0.072, 0.354)	0.122 (0.079, 0.311)	0.13 (0.075, 0.321)	0.118 (0.071, 0.337)
++–	graduation	0	102	95	278	285
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	12 (8, 17)	3 (1, 9)	3 (1, 9)	6 (2, 14)	6 (2, 14)
	n_unique	11 (7, 16)	3 (1, 8)	3 (1, 8)	6 (2, 13)	5 (2, 13)
	post_p	NA (NA, NA)	0.36 (0.17, 0.66)	0.36 (0.19, 0.68)	0.88 (0.51, 0.99)	0.87 (0.48, 0.99)
	rate	0.115 (0.075, 0.178)	0.132 (0.062, 0.439)	0.13 (0.063, 0.445)	0.037 (0.014, 0.095)	0.037 (0.014, 0.1)
++-+	graduation	0	148	149	284	292
	futility	0	0	0	0	0
	max_n	0	0	0	0	2
	n	12 (8, 17)	4 (1, 9)	4 (1, 8)	6 (2, 14)	6 (2, 14)
	n_unique	11 (7, 16)	3 (1, 8)	3 (1, 8)	5 (2, 13)	6 (1, 13)
	post_p	NA (NA, NA)	0.35 (0.16, 0.67)	0.35 (0.18, 0.64)	0.86 (0.51, 0.98)	0.89 (0.57, 0.98)
	rate	0.112 (0.073, 0.171)	0.131 (0.061, 0.39)	0.136 (0.063, 0.397)	0.037 (0.015, 0.093)	0.036 (0.014, 0.08)
+++-	graduation	0	152	149	282	293
	futility	0	0	0	0	0
	max_n	0	6	13	7	7
	n	12 (8, 17)	3 (1, 9)	4 (1, 9)	6 (2, 14)	6 (2, 14)
	n_unique	11 (7, 16)	3 (1, 9)	3 (1, 8)	6 (1, 13)	5 (1, 13)
	post_p	NA (NA, NA)	0.36 (0.16, 0.65)	0.36 (0.18, 0.65)	0.85 (0.54, 0.98)	0.87 (0.52, 0.99)
	rate	0.112 (0.074, 0.179)	0.129 (0.059, 0.333)	0.129 (0.062, 0.392)	0.038 (0.017, 0.085)	0.035 (0.014, 0.087)
++++	graduation	0	183	190	287	299
	futility	0	0	0	0	0
	max_n	0	6	13	7	9
	n	12 (8, 18)	4 (1, 9)	3 (1, 9)	5 (2, 13)	6 (2, 14)
	n_unique	11 (7, 16)	3 (1, 8)	3 (1, 9)	5 (1, 13)	5 (1, 13)
	post_p	NA (NA, NA)	0.38 (0.18, 0.69)	0.36 (0.17, 0.64)	0.86 (0.49, 0.98)	0.88 (0.47, 0.98)
	rate	0.11 (0.071, 0.177)	0.122 (0.057, 0.386)	0.132 (0.061, 0.431)	0.038 (0.015, 0.097)	0.037 (0.015, 0.092)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	10	1	16	10
	time_stop	5 (4, 6)	4 (4, 4)	7 (6, 24)	10 (7, 29)
	n_trt	31 (29, 41)	25 (25, 25)	36 (28, 130)	50 (36, 118)
	n_control	56 (51, 70)	43 (43, 43)	76 (60, 300)	108 (78, 348)
	post_p	0.89 (0.86, 0.93)	0.88 (0.88, 0.88)	1 (0.97, 1)	1 (0.98, 1)
	order	1 (1, 1)	1 (1, 1)	1 (1, 3.5)	1 (1, 6)
TP53- & AR-	count	30	31	123	133
	time_stop	9 (6, 15)	15 (11, 23)	15 (10, 30)	18 (10, 31)
	n_trt	30 (26, 46)	36 (27, 56)	33 (26, 77)	41 (25, 93)
	n_control	43 (27, 67)	63 (51, 111)	69 (41, 149)	79 (46, 148)
	post_p	0.9 (0.86, 0.96)	0.92 (0.88, 0.96)	0.98 (0.91, 1)	0.99 (0.92, 1)
	order	1 (1, 1.1)	1 (1, 3)	2 (1, 3)	2 (1, 3)
TP53+	count	5	2	24	27
	time_stop	9 (8, 10)	8 (7, 10)	13 (9, 22)	16 (10, 32)
	n_trt	29 (26, 30)	26 (25, 28)	33 (26, 60)	39 (27, 103)
	n_control	38 (33, 44)	46 (38, 54)	64 (41, 109)	73 (41, 176)
	post_p	0.95 (0.92, 0.97)	0.9 (0.9, 0.9)	1 (0.94, 1)	1 (0.94, 1)
	order	1 (1, 1)	1.5 (1.1, 1.9)	2 (1, 3.7)	2 (1, 3.4)
DRD+	count		1	267	280
	time_stop		21 (21, 21)	19 (11, 32)	18 (10, 32)
	n_trt		25 (25, 25)	41 (26, 83)	42 (26, 86)
	n_control		69 (69, 69)	57 (28, 100)	50 (27, 108)
	post_p		0.98 (0.98, 0.98)	1 (0.98, 1)	1 (0.98, 1)
	order		1 (1, 1)	2 (1, 4)	2 (1, 3)
TEfus+	count	2	4	31	41
	time_stop	12 (11, 13)	10 (9, 11)	14 (11, 20)	15 (11, 28)
	n_trt	30 (28, 32)	28 (25, 31)	28 (25, 42)	29 (25, 67)
	n_control	50 (45, 54)	32 (31, 42)	51 (42, 79)	57 (40, 103)
	post_p	0.96 (0.94, 0.97)	0.94 (0.88, 0.95)	1 (0.95, 1)	1 (0.97, 1)
	order	1.5 (1.1, 1.9)	1 (1, 1)	2 (1, 3)	2 (1, 4)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	17	2
	time_stop	5 (4, 35)	22 (21, 24)
	n_trt	31 (25, 135)	98 (80, 116)
	n_control	50 (37, 411)	258 (244, 271)
	post_p	0.08 (0, 0.18)	0.01 (0.01, 0.02)
	order	1 (1, 4.4)	4.5 (4.1, 4.9)
TP53- & AR-	count	220	185	8	2
	time_stop	16 (8, 30)	21 (13, 32)	17 (15, 24)	17 (15, 19)
	n_trt	38 (26, 74)	35 (25, 80)	34 (28, 66)	44 (29, 58)
	n_control	74 (32, 148)	101 (55, 162)	71 (60, 140)	89 (75, 103)
	post_p	0.15 (0.05, 0.27)	0.16 (0.05, 0.27)	0.17 (0.12, 0.27)	0.16 (0.13, 0.19)
	order	1 (1, 2)	2 (1, 3)	2 (1, 3.3)	2 (1.2, 2.8)
TP53+	count	63	63	1	1
	time_stop	23 (11, 33)	19 (10, 32)	11 (11, 11)	10 (10, 10)
	n_trt	41 (26, 77)	38 (26, 68)	26 (26, 26)	25 (25, 25)
	n_control	113 (46, 178)	88 (38, 174)	40 (40, 40)	39 (39, 39)
	post_p	0.08 (0.01, 0.24)	0.08 (0.01, 0.22)	0.13 (0.13, 0.13)	0.09 (0.09, 0.09)
	order	2 (1, 4)	1 (1, 3)	1 (1, 1)	1 (1, 1)
DRD+	count	78	92
	time_stop	29 (22, 35)	28 (21, 33)
	n_trt	31 (25, 47)	29 (25, 50)
	n_control	91 (66, 112)	90 (59, 117)
	post_p	0.08 (0.02, 0.24)	0.1 (0.02, 0.22)
	order	2 (1, 4)	2 (1, 4)
TEfus+	count	59	68
	time_stop	23 (16, 32)	23 (13, 32)
	n_trt	35 (26, 55)	40 (27, 64)
	n_control	94 (60, 142)	91 (46, 140)
	post_p	0.07 (0.01, 0.19)	0.06 (0.02, 0.21)
	order	2 (1, 4)	2 (1, 4)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10
		time	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)
		n	15 (13, 16)	2 (1, 5)	8 (6, 10)	4 (1, 7)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 2)	0 (0, 3)	2 (0, 3)	0 (0, 1)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)
		post_p	0.74 (0.64, 0.93)	0.6 (0.52, 0.65)	0.68 (0.6, 0.78)	0.7 (0.54, 0.75)	NA (NA, NA)	0.53 (0.51, 0.59)	0.51 (0.51, 0.51)	0.54 (0.53, 0.55)	0.65 (0.57, 0.7)	0.64 (0.52, 0.74)	0.56 (0.55, 0.6)	0.57 (0.53, 0.6)	NA (NA, NA)	0.51 (0.51, 0.51)	0.52 (0.52, 0.52)	0.51 (0.5, 0.53)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.045 (0.023, 0.073)	0.043 (0, 0.204)	0.039 (0, 0.08)	0 (0, 0.113)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.125)	0 (0, 0)	0 (0, 0.099)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Taxel_therapies	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)
		n	5 (5, 5)	0 (0, 0)	7 (7, 7)	4 (4, 4)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (2, 2)	0 (0, 0)	2 (2, 2)	5 (5, 5)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		post_p	0.76 (0.76, 0.76)	NA (NA, NA)	0.53 (0.53, 0.53)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.76 (0.76, 0.76)	NA (NA, NA)	0.51 (0.51, 0.51)	0.58 (0.58, 0.58)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0.12 (0.12, 0.12)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0.069 (0.069, 0.069)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
	Carboplatin	count	16	16	16	16	16	16	16	16	16	16	16	16	16	16	16	16
		time	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)
		n	8 (2, 26)	2 (0, 6)	6 (3, 20)	3 (0, 14)	4 (0, 8)	3 (1, 6)	2 (0, 4)	1 (0, 4)	0 (0, 7)	2 (0, 6)	1 (0, 5)	1 (0, 7)	2 (0, 6)	3 (1, 6)	2 (1, 6)	2 (0, 4)
		post_p	0.71 (0.6, 0.8)	0.64 (0.55, 0.71)	0.63 (0.53, 0.7)	0.59 (0.56, 0.7)	0.58 (0.5, 0.76)	0.64 (0.54, 0.8)	0.58 (0.53, 0.8)	0.58 (0.52, 0.71)	0.54 (0.51, 0.7)	0.59 (0.54, 0.74)	0.56 (0.51, 0.65)	0.61 (0.51, 0.74)	0.73 (0.55, 0.93)	0.61 (0.53, 0.82)	0.67 (0.53, 0.87)	0.63 (0.51, 0.71)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.036 (0, 0.094)	0 (0, 0.093)	0.074 (0, 0.099)	0.017 (0, 0.121)	0 (0, 0.049)	0 (0, 0.074)	0 (0, 0.04)	0 (0, 0.039)	0 (0, 0.119)	0 (0, 0.095)	0 (0, 0.091)	0 (0, 0.097)	0 (0, 0.028)	0 (0, 0.044)	0 (0, 0.042)	0 (0, 0.075)
	Niraparib	count	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10
		time	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)
		n	11 (4, 31)	2 (0, 4)	8 (5, 24)	4 (2, 13)	3 (0, 8)	6 (5, 7)	2 (1, 6)	3 (1, 4)	2 (0, 13)	0 (0, 4)	1 (1, 6)	2 (0, 3)	2 (1, 4)	3 (1, 5)	3 (2, 4)	2 (0, 4)
		post_p	0.65 (0.5, 0.84)	0.7 (0.54, 0.81)	0.6 (0.55, 0.88)	0.68 (0.61, 0.86)	0.7 (0.56, 0.95)	0.73 (0.61, 0.96)	0.67 (0.6, 0.8)	0.64 (0.53, 0.77)	0.58 (0.51, 0.75)	0.57 (0.55, 0.6)	0.56 (0.5, 0.69)	0.56 (0.52, 0.8)	0.76 (0.56, 0.96)	0.61 (0.52, 0.89)	0.69 (0.59, 0.81)	0.7 (0.51, 0.89)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.09 (0.028, 0.116)	0.059 (0, 0.08)	0.097 (0, 0.127)	0.027 (0, 0.069)	0.025 (0, 0.033)	0.032 (0, 0.066)	0 (0, 0.053)	0.039 (0, 0.089)	0.046 (0, 0.099)	0.072 (0.026, 0.091)	0 (0, 0.134)	0 (0, 0.108)	0 (0, 0.022)	0.004 (0, 0.11)	0.025 (0, 0.069)	0 (0, 0.025)
TP53- & AR-	Hormone_therapies	count	30	30			30	30
		time	9 (6, 15)	9 (6, 15)			9 (6, 15)	9 (6, 15)
		n	24 (20, 34)	3 (2, 8)			1 (0, 5)	1 (0, 3)
		post_p	0.89 (0.76, 0.96)	0.63 (0.52, 0.85)			0.62 (0.5, 0.74)	0.55 (0.51, 0.68)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.067 (0.035, 0.102)	0.056 (0, 0.121)			0 (0, 0.07)	0 (0, 0.071)
	Taxel_therapies	count	31	31			31	31
		time	15 (11, 23)	15 (11, 23)			15 (11, 23)	15 (11, 23)
		n	27 (16, 36)	5 (2, 13)			3 (0, 5)	2 (0, 5)
		post_p	0.79 (0.73, 0.91)	0.72 (0.54, 0.91)			0.58 (0.51, 0.73)	0.58 (0.52, 0.79)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.076 (0.056, 0.096)	0.06 (0, 0.112)			0.048 (0, 0.097)	0.016 (0, 0.077)
	Carboplatin	count	123	123			123	123
		time	15 (10, 30)	15 (10, 30)			15 (10, 30)	15 (10, 30)
		n	19 (12, 48)	3 (1, 8)			6 (3, 15)	6 (3, 15)
		post_p	0.78 (0.71, 0.91)	0.61 (0.51, 0.79)			0.79 (0.54, 0.98)	0.78 (0.56, 0.98)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.076 (0.04, 0.103)	0.068 (0, 0.114)			0.031 (0, 0.071)	0.03 (0, 0.066)
	Niraparib	count	133	133			133	133
		time	18 (10, 31)	18 (10, 31)			18 (10, 31)	18 (10, 31)
		n	20 (12, 61)	4 (1, 12)			6 (3, 14)	8 (3, 14)
		post_p	0.76 (0.71, 0.93)	0.64 (0.51, 0.81)			0.87 (0.62, 0.98)	0.82 (0.67, 0.97)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.079 (0.047, 0.104)	0.074 (0, 0.126)			0.032 (0, 0.06)	0.031 (0, 0.06)
TP53+	Hormone_therapies	count			5	5			5	5			5	5			5	5
		time			9 (8, 10)	9 (8, 10)			9 (8, 10)	9 (8, 10)			9 (8, 10)	9 (8, 10)			9 (8, 10)	9 (8, 10)
		n			16 (14, 19)	4 (3, 7)			2 (1, 3)	0 (0, 2)			2 (0, 3)	1 (0, 3)			1 (0, 2)	0 (0, 1)
		post_p			0.86 (0.8, 0.94)	0.73 (0.66, 0.78)			0.58 (0.55, 0.61)	0.6 (0.55, 0.64)			0.6 (0.57, 0.76)	0.59 (0.54, 0.66)			0.54 (0.51, 0.57)	0.5 (0.5, 0.5)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.041 (0.022, 0.071)	0.048 (0, 0.063)			0 (0, 0)	0 (0, 0)			0 (0, 0.081)	0 (0, 0)			0 (0, 0)	0 (0, 0)
	Taxel_therapies	count			2	2			2	2			2	2			2	2
		time			8 (7, 10)	8 (7, 10)			8 (7, 10)	8 (7, 10)			8 (7, 10)	8 (7, 10)			8 (7, 10)	8 (7, 10)
		n			6 (3, 10)	8 (5, 11)			1 (1, 1)	2 (0, 3)			3 (3, 3)	4 (3, 6)			0 (0, 1)	2 (1, 2)
		post_p			0.63 (0.56, 0.71)	0.74 (0.73, 0.74)			0.51 (0.5, 0.52)	0.55 (0.55, 0.55)			0.6 (0.56, 0.63)	0.76 (0.63, 0.89)			0.51 (0.51, 0.51)	0.56 (0.55, 0.58)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.126 (0.098, 0.155)	0.054 (0.011, 0.097)			0 (0, 0)	0 (0, 0)			0.078 (0.061, 0.096)	0 (0, 0)			0 (0, 0)	0 (0, 0)
	Carboplatin	count			24	24			24	24			24	24			24	24
		time			13 (9, 22)	13 (9, 22)			13 (9, 22)	13 (9, 22)			13 (9, 22)	13 (9, 22)			13 (9, 22)	13 (9, 22)
		n			10 (4, 17)	5 (1, 15)			4 (1, 7)	2 (1, 6)			3 (1, 5)	3 (0, 7)			3 (1, 8)	3 (1, 6)
		post_p			0.79 (0.55, 0.89)	0.72 (0.54, 0.8)			0.66 (0.56, 0.86)	0.64 (0.54, 0.8)			0.63 (0.53, 0.78)	0.68 (0.56, 0.86)			0.65 (0.54, 0.87)	0.69 (0.56, 0.85)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.071 (0.008, 0.101)	0.076 (0, 0.11)			0 (0, 0.041)	0.037 (0, 0.06)			0.058 (0, 0.11)	0.057 (0, 0.11)			0 (0, 0.076)	0 (0, 0.079)
	Niraparib	count			27	27			27	27			27	27			27	27
		time			16 (10, 32)	16 (10, 32)			16 (10, 32)	16 (10, 32)			16 (10, 32)	16 (10, 32)			16 (10, 32)	16 (10, 32)
		n			16 (5, 34)	7 (3, 22)			4 (1, 7)	3 (0, 7)			3 (0, 11)	2 (1, 10)			4 (1, 11)	3 (2, 7)
		post_p			0.75 (0.57, 0.91)	0.71 (0.57, 0.9)			0.78 (0.61, 0.91)	0.69 (0.51, 0.87)			0.7 (0.52, 0.89)	0.63 (0.54, 0.88)			0.74 (0.52, 0.95)	0.72 (0.54, 0.89)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.086 (0.055, 0.107)	0.08 (0.028, 0.112)			0.03 (0, 0.085)	0.032 (0, 0.078)			0.056 (0, 0.104)	0.067 (0, 0.111)			0.027 (0, 0.07)	0.014 (0, 0.065)
DRD+	Taxel_therapies	count					1	1	1	1					1	1	1	1
		time					21 (21, 21)	21 (21, 21)	21 (21, 21)	21 (21, 21)					21 (21, 21)	21 (21, 21)	21 (21, 21)	21 (21, 21)
		n					4 (4, 4)	4 (4, 4)	4 (4, 4)	0 (0, 0)					1 (1, 1)	5 (5, 5)	3 (3, 3)	4 (4, 4)
		post_p					0.67 (0.67, 0.67)	0.54 (0.54, 0.54)	0.5 (0.5, 0.5)	NA (NA, NA)					0.5 (0.5, 0.5)	0.84 (0.84, 0.84)	0.87 (0.87, 0.87)	0.5 (0.5, 0.5)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.06 (0.06, 0.06)	0.114 (0.114, 0.114)	0.081 (0.081, 0.081)	NA (NA, NA)					0 (0, 0)	0.039 (0.039, 0.039)	0 (0, 0)	0.07 (0.07, 0.07)
	Carboplatin	count					267	267	267	267					267	267	267	267
		time					19 (11, 32)	19 (11, 32)	19 (11, 32)	19 (11, 32)					19 (11, 32)	19 (11, 32)	19 (11, 32)	19 (11, 32)
		n					7 (3, 17)	8 (3, 16)	5 (2, 11)	5 (1, 11)					4 (1, 10)	4 (2, 11)	4 (1, 11)	4 (1, 11)
		post_p					0.81 (0.6, 0.97)	0.81 (0.62, 0.97)	0.74 (0.56, 0.95)	0.74 (0.53, 0.94)					0.74 (0.54, 0.93)	0.75 (0.54, 0.94)	0.74 (0.55, 0.93)	0.74 (0.54, 0.95)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.035 (0, 0.064)	0.033 (0, 0.064)	0.028 (0, 0.068)	0.03 (0, 0.071)					0.029 (0, 0.074)	0.029 (0, 0.077)	0.031 (0, 0.068)	0.028 (0, 0.068)
	Niraparib	count					280	280	280	280					280	280	280	280
		time					18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)					18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)
		n					7 (3, 16)	8 (3, 17)	4 (1, 11)	4 (1, 10)					4 (1, 11)	4 (1, 11)	4 (2, 11)	4 (1, 11)
		post_p					0.8 (0.59, 0.98)	0.82 (0.62, 0.98)	0.74 (0.54, 0.93)	0.72 (0.54, 0.93)					0.74 (0.54, 0.93)	0.76 (0.56, 0.94)	0.72 (0.53, 0.92)	0.75 (0.54, 0.95)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.032 (0, 0.07)	0.029 (0, 0.06)	0.028 (0, 0.071)	0.03 (0, 0.072)					0.028 (0, 0.07)	0.027 (0, 0.068)	0.029 (0, 0.072)	0.026 (0, 0.068)
TEfus+	Hormone_therapies	count		2		2		2		2		2		2		2		2
		time		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)
		n		6 (3, 8)		14 (10, 18)		1 (0, 2)		2 (0, 3)		2 (1, 4)		3 (2, 4)		2 (1, 2)		2 (0, 3)
		post_p		0.75 (0.69, 0.81)		0.87 (0.83, 0.91)		0.69 (0.69, 0.69)		0.5 (0.5, 0.5)		0.66 (0.61, 0.71)		0.52 (0.51, 0.52)		0.54 (0.54, 0.54)		0.59 (0.59, 0.59)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.017 (0.003, 0.031)		0.055 (0.05, 0.061)		0 (0, 0)		0 (0, 0)		0.031 (0.006, 0.056)		0.025 (0.005, 0.045)		0 (0, 0)		0 (0, 0)
	Taxel_therapies	count		4		4		4		4		4		4		4		4
		time		10 (9, 11)		10 (9, 11)		10 (9, 11)		10 (9, 11)		10 (9, 11)		10 (9, 11)		10 (9, 11)		10 (9, 11)
		n		4 (4, 5)		8 (6, 13)		1 (0, 3)		1 (0, 2)		4 (3, 6)		3 (3, 4)		2 (1, 4)		2 (1, 2)
		post_p		0.68 (0.65, 0.74)		0.81 (0.66, 0.95)		0.58 (0.52, 0.72)		0.52 (0.52, 0.53)		0.7 (0.56, 0.94)		0.7 (0.64, 0.75)		0.54 (0.51, 0.64)		0.53 (0.52, 0.61)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.054 (0.048, 0.096)		0.085 (0.063, 0.088)		0 (0, 0)		0 (0, 0)		0.043 (0, 0.086)		0.1 (0.067, 0.145)		0 (0, 0)		0 (0, 0)
	Carboplatin	count		31		31		31		31		31		31		31		31
		time		14 (11, 20)		14 (11, 20)		14 (11, 20)		14 (11, 20)		14 (11, 20)		14 (11, 20)		14 (11, 20)		14 (11, 20)
		n		3 (1, 5)		6 (3, 14)		5 (4, 8)		3 (2, 6)		2 (1, 5)		3 (1, 7)		3 (1, 5)		4 (1, 5)
		post_p		0.61 (0.51, 0.73)		0.73 (0.53, 0.8)		0.77 (0.61, 0.92)		0.73 (0.55, 0.91)		0.61 (0.53, 0.85)		0.68 (0.54, 0.8)		0.68 (0.58, 0.82)		0.7 (0.53, 0.85)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.071 (0, 0.127)		0.075 (0.04, 0.1)		0.03 (0, 0.061)		0 (0, 0.064)		0.036 (0, 0.115)		0.045 (0, 0.117)		0.031 (0, 0.087)		0.008 (0, 0.076)
	Niraparib	count		41		41		41		41		41		41		41		41
		time		15 (11, 28)		15 (11, 28)		15 (11, 28)		15 (11, 28)		15 (11, 28)		15 (11, 28)		15 (11, 28)		15 (11, 28)
		n		3 (1, 7)		7 (3, 18)		7 (4, 12)		3 (2, 7)		3 (1, 7)		3 (0, 7)		4 (1, 8)		3 (1, 8)
		post_p		0.64 (0.53, 0.84)		0.75 (0.6, 0.86)		0.83 (0.72, 0.94)		0.72 (0.54, 0.89)		0.6 (0.52, 0.84)		0.67 (0.55, 0.81)		0.71 (0.52, 0.88)		0.7 (0.55, 0.92)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.059 (0, 0.098)		0.066 (0, 0.097)		0.019 (0, 0.054)		0.023 (0, 0.069)		0.033 (0, 0.12)		0.065 (0, 0.113)		0.029 (0, 0.086)		0.014 (0, 0.07)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17
		time	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)
		n	15 (11, 32)	2 (1, 6)	7 (4, 29)	2 (1, 9)	0 (0, 4)	0 (0, 7)	0 (0, 3)	0 (0, 2)	2 (0, 12)	2 (0, 5)	1 (0, 6)	2 (0, 6)	0 (0, 3)	0 (0, 4)	0 (0, 3)	0 (0, 2)
		post_p	0.27 (0.05, 0.45)	0.32 (0.23, 0.41)	0.33 (0.16, 0.39)	0.34 (0.26, 0.43)	0.33 (0.17, 0.5)	0.39 (0.29, 0.47)	0.18 (0.16, 0.37)	0.36 (0.31, 0.46)	0.36 (0.19, 0.48)	0.36 (0.25, 0.45)	0.33 (0.22, 0.48)	0.41 (0.37, 0.49)	0.39 (0.26, 0.47)	0.33 (0.27, 0.47)	0.4 (0.13, 0.46)	0.36 (0.33, 0.41)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.134 (0.078, 0.274)	0.18 (0.041, 0.346)	0.177 (0.117, 0.27)	0.228 (0.054, 0.6)	0.152 (0, 0.594)	0.108 (0.097, 0.839)	0.192 (0.06, 0.826)	0.974 (0.082, 5.57)	0.081 (0, 0.225)	0.158 (0, 0.272)	0.155 (0, 0.766)	0.19 (0.041, 0.258)	0.151 (0.076, 0.539)	0.108 (0, 0.205)	0.142 (0, 0.294)	0.33 (0.124, 27.05)
	Taxel_therapies	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)
		n	27 (21, 33)	6 (4, 7)	8 (6, 9)	9 (4, 14)	3 (2, 4)	10 (5, 14)	3 (2, 4)	3 (2, 4)	6 (5, 6)	4 (4, 4)	2 (2, 3)	6 (5, 8)	4 (2, 5)	2 (1, 4)	5 (3, 7)	2 (1, 2)
		post_p	0.38 (0.35, 0.41)	0.31 (0.29, 0.33)	0.22 (0.22, 0.22)	0.3 (0.19, 0.41)	0.28 (0.27, 0.29)	0.24 (0.2, 0.29)	0.23 (0.2, 0.26)	0.38 (0.37, 0.4)	0.3 (0.15, 0.45)	0.45 (0.44, 0.45)	0.25 (0.17, 0.32)	0.39 (0.38, 0.41)	0.37 (0.3, 0.44)	0.18 (0.08, 0.28)	0.3 (0.22, 0.38)	0.19 (0.06, 0.33)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.13 (0.123, 0.138)	0.183 (0.156, 0.209)	0.226 (0.199, 0.253)	0.276 (0.167, 0.386)	0.263 (0.176, 0.349)	0.176 (0.143, 0.209)	0.223 (0.202, 0.245)	0.173 (0.123, 0.223)	0.223 (0.142, 0.305)	0.215 (0.207, 0.223)	0.285 (0.26, 0.309)	0.144 (0.127, 0.162)	0.069 (0.065, 0.074)	0.224 (0.174, 0.275)	0.802 (0.26, 1.345)	0.239 (0.236, 0.242)
TP53- & AR-	Hormone_therapies	count	220	220			220	220
		time	16 (8, 30)	16 (8, 30)			16 (8, 30)	16 (8, 30)
		n	24 (16, 56)	5 (2, 11)			3 (0, 8)	3 (0, 7)
		post_p	0.32 (0.11, 0.47)	0.38 (0.18, 0.49)			0.35 (0.17, 0.48)	0.36 (0.17, 0.48)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.128 (0.107, 0.173)	0.153 (0.089, 0.349)			0.139 (0.071, 0.538)	0.141 (0.069, 0.58)
	Taxel_therapies	count	185	185			185	185
		time	21 (13, 32)	21 (13, 32)			21 (13, 32)	21 (13, 32)
		n	21 (10, 60)	6 (3, 13)			4 (1, 10)	4 (1, 9)
		post_p	0.34 (0.1, 0.47)	0.34 (0.15, 0.47)			0.32 (0.16, 0.47)	0.32 (0.15, 0.47)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.128 (0.106, 0.193)	0.155 (0.107, 0.345)			0.151 (0.083, 0.55)	0.142 (0.085, 0.428)
	Carboplatin	count	8	8			8	8
		time	17 (15, 24)	17 (15, 24)			17 (15, 24)	17 (15, 24)
		n	24 (16, 42)	3 (1, 12)			4 (1, 7)	4 (2, 12)
		post_p	0.28 (0.12, 0.44)	0.39 (0.17, 0.44)			0.29 (0.12, 0.43)	0.41 (0.32, 0.46)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.14 (0.117, 0.189)	0.164 (0.107, 0.225)			0.212 (0.085, 0.539)	0.118 (0.055, 0.288)
	Niraparib	count	2	2			2	2
		time	17 (15, 19)	17 (15, 19)			17 (15, 19)	17 (15, 19)
		n	32 (18, 47)	2 (2, 3)			4 (3, 4)	5 (4, 6)
		post_p	0.34 (0.27, 0.41)	0.21 (0.16, 0.26)			0.3 (0.2, 0.39)	0.4 (0.39, 0.4)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.138 (0.121, 0.155)	0.573 (0.374, 0.773)			0.231 (0.144, 0.318)	0.118 (0.084, 0.153)
TP53+	Hormone_therapies	count			63	63			63	63			63	63			63	63
		time			23 (11, 33)	23 (11, 33)			23 (11, 33)	23 (11, 33)			23 (11, 33)	23 (11, 33)			23 (11, 33)	23 (11, 33)
		n			14 (8, 32)	8 (3, 22)			2 (1, 5)	2 (0, 7)			4 (1, 10)	3 (1, 7)			2 (0, 6)	2 (1, 6)
		post_p			0.3 (0.12, 0.47)	0.36 (0.12, 0.48)			0.35 (0.2, 0.47)	0.36 (0.21, 0.47)			0.36 (0.22, 0.47)	0.36 (0.22, 0.48)			0.37 (0.2, 0.45)	0.34 (0.17, 0.46)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.142 (0.111, 0.217)	0.139 (0.097, 0.316)			0.172 (0.066, 0.67)	0.153 (0.082, 0.595)			0.171 (0.097, 0.83)	0.176 (0.1, 0.546)			0.175 (0.075, 0.397)	0.181 (0.09, 0.828)
	Taxel_therapies	count			63	63			63	63			63	63			63	63
		time			19 (10, 32)	19 (10, 32)			19 (10, 32)	19 (10, 32)			19 (10, 32)	19 (10, 32)			19 (10, 32)	19 (10, 32)
		n			9 (5, 25)	11 (5, 19)			2 (0, 4)	2 (0, 5)			4 (2, 9)	4 (1, 9)			2 (0, 6)	2 (0, 5)
		post_p			0.28 (0.16, 0.45)	0.37 (0.17, 0.48)			0.36 (0.22, 0.47)	0.33 (0.15, 0.48)			0.36 (0.17, 0.46)	0.35 (0.19, 0.45)			0.35 (0.22, 0.48)	0.39 (0.2, 0.5)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.146 (0.103, 0.254)	0.143 (0.103, 0.241)			0.162 (0.069, 0.646)	0.171 (0.078, 0.503)			0.162 (0.11, 0.422)	0.177 (0.102, 0.42)			0.159 (0.069, 0.531)	0.141 (0.062, 0.552)
	Carboplatin	count			1	1			1	1			1	1			1	1
		time			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)
		n			12 (12, 12)	5 (5, 5)			0 (0, 0)	2 (2, 2)			1 (1, 1)	1 (1, 1)			3 (3, 3)	2 (2, 2)
		post_p			0.36 (0.36, 0.36)	0.47 (0.47, 0.47)			NA (NA, NA)	0.38 (0.38, 0.38)			0.34 (0.34, 0.34)	0.34 (0.34, 0.34)			0.5 (0.5, 0.5)	0.36 (0.36, 0.36)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.17 (0.17, 0.17)	0.092 (0.092, 0.092)			NA (NA, NA)	0.165 (0.165, 0.165)			0.301 (0.301, 0.301)	0.565 (0.565, 0.565)			0.078 (0.078, 0.078)	0.592 (0.592, 0.592)
	Niraparib	count			1	1			1	1			1	1			1	1
		time			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)
		n			6 (6, 6)	2 (2, 2)			4 (4, 4)	3 (3, 3)			3 (3, 3)	1 (1, 1)			3 (3, 3)	3 (3, 3)
		post_p			0.21 (0.21, 0.21)	0.28 (0.28, 0.28)			0.44 (0.44, 0.44)	0.33 (0.33, 0.33)			0.4 (0.4, 0.4)	0.21 (0.21, 0.21)			0.48 (0.48, 0.48)	0.46 (0.46, 0.46)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.195 (0.195, 0.195)	0.365 (0.365, 0.365)			0.077 (0.077, 0.077)	0.139 (0.139, 0.139)			0.277 (0.277, 0.277)	0.36 (0.36, 0.36)			0 (0, 0)	0.086 (0.086, 0.086)
DRD+	Hormone_therapies	count					78	78	78	78					78	78	78	78
		time					29 (22, 35)	29 (22, 35)	29 (22, 35)	29 (22, 35)					29 (22, 35)	29 (22, 35)	29 (22, 35)	29 (22, 35)
		n					4 (2, 10)	5 (1, 12)	3 (1, 8)	3 (1, 7)					3 (1, 7)	4 (1, 6)	4 (1, 7)	3 (1, 7)
		post_p					0.33 (0.12, 0.48)	0.31 (0.17, 0.45)	0.3 (0.16, 0.45)	0.32 (0.18, 0.45)					0.33 (0.18, 0.46)	0.31 (0.16, 0.47)	0.32 (0.15, 0.46)	0.35 (0.19, 0.44)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.158 (0.091, 0.488)	0.125 (0.087, 0.35)	0.172 (0.083, 0.679)	0.152 (0.089, 0.578)					0.147 (0.092, 0.599)	0.173 (0.101, 0.493)	0.15 (0.093, 0.422)	0.148 (0.093, 0.524)
	Taxel_therapies	count					92	92	92	92					92	92	92	92
		time					28 (21, 33)	28 (21, 33)	28 (21, 33)	28 (21, 33)					28 (21, 33)	28 (21, 33)	28 (21, 33)	28 (21, 33)
		n					5 (2, 11)	5 (2, 11)	3 (1, 7)	3 (1, 7)					3 (1, 6)	3 (1, 8)	3 (1, 7)	3 (1, 8)
		post_p					0.31 (0.17, 0.47)	0.32 (0.13, 0.48)	0.34 (0.2, 0.46)	0.33 (0.15, 0.47)					0.33 (0.17, 0.46)	0.34 (0.16, 0.45)	0.35 (0.19, 0.48)	0.3 (0.14, 0.46)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.133 (0.089, 0.302)	0.143 (0.083, 0.37)	0.16 (0.085, 0.473)	0.144 (0.094, 0.51)					0.167 (0.09, 1.203)	0.139 (0.085, 0.447)	0.157 (0.083, 0.424)	0.153 (0.096, 0.646)
TEfus+	Hormone_therapies	count		59		59		59		59		59		59		59		59
		time		23 (16, 32)		23 (16, 32)		23 (16, 32)		23 (16, 32)		23 (16, 32)		23 (16, 32)		23 (16, 32)		23 (16, 32)
		n		4 (2, 9)		9 (4, 22)		4 (0, 9)		3 (0, 6)		3 (1, 9)		3 (1, 7)		2 (1, 5)		3 (1, 6)
		post_p		0.31 (0.12, 0.46)		0.34 (0.14, 0.47)		0.32 (0.16, 0.47)		0.37 (0.22, 0.46)		0.31 (0.18, 0.46)		0.34 (0.2, 0.46)		0.33 (0.21, 0.47)		0.35 (0.18, 0.48)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.186 (0.112, 0.525)		0.156 (0.111, 0.265)		0.13 (0.087, 0.658)		0.139 (0.076, 0.586)		0.188 (0.108, 0.682)		0.179 (0.107, 0.386)		0.162 (0.086, 0.545)		0.148 (0.077, 0.501)
	Taxel_therapies	count		68		68		68		68		68		68		68		68
		time		23 (13, 32)		23 (13, 32)		23 (13, 32)		23 (13, 32)		23 (13, 32)		23 (13, 32)		23 (13, 32)		23 (13, 32)
		n		5 (2, 11)		10 (6, 26)		3 (1, 7)		2 (1, 5)		5 (2, 10)		5 (2, 8)		2 (1, 7)		3 (0, 7)
		post_p		0.33 (0.13, 0.47)		0.29 (0.1, 0.47)		0.31 (0.16, 0.46)		0.32 (0.18, 0.48)		0.34 (0.19, 0.49)		0.35 (0.17, 0.48)		0.35 (0.16, 0.48)		0.39 (0.18, 0.48)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.165 (0.112, 0.418)		0.142 (0.102, 0.298)		0.165 (0.082, 0.497)		0.163 (0.076, 0.363)		0.16 (0.095, 0.326)		0.167 (0.099, 0.443)		0.155 (0.079, 0.453)		0.146 (0.063, 0.393)