Setting description

Carboplatin more effective in the DRD+ biomarker signature

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66
DRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 10 1 16 10
TP53- & AR- 30 31 123 133
TP53+ 5 2 24 27
DRD+ 0 1 267 280
TEfus+ 2 4 31 41
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.020 0.002 0.032 0.020
TP53- & AR- 0.060 0.062 0.246 0.266
TP53+ 0.010 0.004 0.048 0.054
DRD+ 0.000 0.002 0.534 0.560
TEfus+ 0.004 0.008 0.062 0.082
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 17 2 0 0
TP53- & AR- 220 185 8 2
TP53+ 63 63 1 1
DRD+ 78 92 0 0
TEfus+ 59 68 0 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.034 0.004 0.000 0.000
TP53- & AR- 0.440 0.370 0.016 0.004
TP53+ 0.126 0.126 0.002 0.002
DRD+ 0.156 0.184 0.000 0.000
TEfus+ 0.118 0.136 0.000 0.000
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 18 15 11 13
TP53+ 6 14 8 8
DRD+ 0 0 0 0
TEfus+ 0 0 0 2
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.036 0.030 0.022 0.026
TP53+ 0.012 0.028 0.016 0.016
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000 0.004


Errors & power

The overall error was 0.372.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.094             0.076             0.136             0.130 

The overall power was 0.786.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.000             0.534             0.560 

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 10 1 16 10
futility 0 17 2 0 0
max_n 0 0 0 0 0
n 430 (397, 463) 176 (109, 252) 181 (121, 262) 184 (109, 254) 184 (117, 256)
n_unique 394 (364, 424) 162 (100, 235) 169 (110, 247) 170 (98, 239) 169 (107, 238)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 5 (4, 33) 21 (7, 23) 7 (6, 24) 10 (7, 29)
post_p NA (NA, NA) 0.41 (0.06, 0.84) 0.46 (0.08, 0.85) 1 (1, 1) 1 (1, 1)
rate 0.112 (0.105, 0.12) 0.114 (0.103, 0.129) 0.112 (0.102, 0.126) 0.072 (0.062, 0.084) 0.072 (0.062, 0.085)
TP53- & AR- graduation 0 30 31 123 133
futility 0 220 185 8 2
max_n 0 18 15 11 13
n 180 (155, 205) 58 (26, 133) 64 (26, 128) 62 (27, 124) 65 (28, 125)
n_unique 166 (142, 188) 55 (25, 126) 59 (24, 121) 57 (25, 116) 59 (26, 117)
time_trial 36 (36, 36) 36 (10, 36) 36 (16, 36) 36 (14, 36) 36 (15, 36)
time_stop NA (NA, NA) 16 (7, 29) 20 (12, 32) 16 (10, 30) 18 (10, 31)
post_p NA (NA, NA) 0.41 (0.06, 0.83) 0.42 (0.08, 0.87) 0.99 (0.81, 1) 0.99 (0.82, 1)
rate 0.112 (0.101, 0.126) 0.117 (0.097, 0.146) 0.114 (0.097, 0.149) 0.072 (0.053, 0.093) 0.074 (0.052, 0.095)
TP53+ graduation 0 5 2 24 27
futility 0 63 63 1 1
max_n 0 6 14 8 8
n 190 (167, 211) 82 (37, 124) 86 (46, 126) 86 (47, 125) 83 (47, 124)
n_unique 172 (152, 193) 76 (34, 115) 79 (40, 118) 78 (42, 119) 78 (42, 114)
time_trial 36 (36, 36) 36 (29, 36) 36 (26, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 22 (9, 32) 19 (10, 32) 13 (9, 22) 16 (10, 32)
post_p NA (NA, NA) 0.4 (0.06, 0.84) 0.4 (0.07, 0.87) 0.99 (0.84, 1) 0.99 (0.84, 1)
rate 0.112 (0.101, 0.124) 0.113 (0.099, 0.141) 0.114 (0.097, 0.138) 0.075 (0.06, 0.093) 0.075 (0.059, 0.093)
DRD+ graduation 0 0 1 267 280
futility 0 78 92 0 0
max_n 0 0 0 0 0
n 118 (101, 135) 34 (19, 63) 36 (24, 63) 67 (27, 102) 65 (27, 103)
n_unique 107 (90, 123) 30 (17, 56) 32 (22, 57) 62 (25, 95) 60 (25, 96)
time_trial 36 (36, 36) 36 (31, 36) 36 (28, 36) 34 (12, 36) 32 (12, 36)
time_stop NA (NA, NA) 29 (22, 35) 28 (21, 33) 19 (11, 32) 18 (10, 32)
post_p NA (NA, NA) 0.36 (0.07, 0.77) 0.36 (0.08, 0.8) 1 (1, 1) 1 (1, 1)
rate 0.112 (0.098, 0.126) 0.115 (0.092, 0.152) 0.114 (0.09, 0.145) 0.036 (0.029, 0.045) 0.036 (0.028, 0.044)
TEfus+ graduation 0 2 4 31 41
futility 0 59 68 0 0
max_n 0 0 0 0 2
n 157 (139, 177) 63 (31, 91) 72 (40, 101) 70 (37, 105) 68 (40, 103)
n_unique 143 (126, 161) 57 (29, 84) 67 (37, 92) 64 (34, 98) 63 (37, 95)
time_trial 36 (36, 36) 36 (30, 36) 36 (27, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 23 (16, 32) 23 (10, 32) 14 (11, 20) 15 (11, 28)
post_p NA (NA, NA) 0.4 (0.07, 0.82) 0.39 (0.07, 0.8) 1 (0.94, 1) 1 (0.95, 1)
rate 0.112 (0.1, 0.125) 0.114 (0.095, 0.144) 0.115 (0.097, 0.136) 0.064 (0.051, 0.082) 0.065 (0.049, 0.079)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 273 217 144 142
futility 0 0 0 0 0
max_n 0 18 15 11 13
n 114 (93, 135) 35 (16, 102) 36 (12, 95) 27 (9, 84) 29 (10, 89)
n_unique 106 (86, 126) 33 (16, 98) 34 (10, 90) 25 (8, 80) 26 (8, 84)
post_p NA (NA, NA) 0.44 (0.1, 0.87) 0.46 (0.1, 0.87) 0.46 (0.1, 0.89) 0.48 (0.08, 0.88)
rate 0.113 (0.099, 0.131) 0.118 (0.097, 0.159) 0.116 (0.095, 0.175) 0.117 (0.09, 0.186) 0.115 (0.092, 0.179)
—+ graduation 0 294 248 167 167
futility 0 0 0 0 0
max_n 0 18 14 11 14
n 22 (15, 30) 7 (2, 20) 8 (3, 22) 6 (2, 17) 6 (2, 18)
n_unique 20 (14, 27) 6 (2, 19) 8 (3, 20) 5 (1, 17) 5 (1, 16)
post_p NA (NA, NA) 0.43 (0.18, 0.81) 0.44 (0.16, 0.85) 0.47 (0.18, 0.82) 0.44 (0.18, 0.81)
rate 0.113 (0.081, 0.156) 0.128 (0.08, 0.289) 0.125 (0.081, 0.272) 0.12 (0.072, 0.279) 0.125 (0.071, 0.326)
–+- graduation 0 90 66 39 37
futility 0 0 0 0 0
max_n 0 6 14 8 8
n 63 (50, 77) 28 (8, 60) 24 (7, 55) 22 (6, 50) 23 (6, 53)
n_unique 57 (45, 72) 26 (8, 56) 22 (6, 52) 20 (5, 47) 21 (6, 49)
post_p NA (NA, NA) 0.45 (0.11, 0.87) 0.41 (0.1, 0.86) 0.44 (0.12, 0.87) 0.45 (0.1, 0.88)
rate 0.113 (0.093, 0.138) 0.119 (0.092, 0.181) 0.121 (0.091, 0.206) 0.118 (0.09, 0.21) 0.118 (0.089, 0.218)
–++ graduation 0 127 121 63 66
futility 0 0 0 0 0
max_n 0 6 13 8 10
n 42 (33, 53) 16 (4, 37) 21 (7, 43) 15 (4, 35) 13 (4, 33)
n_unique 39 (30, 49) 15 (4, 35) 19 (6, 40) 14 (3, 33) 12 (3, 31)
post_p NA (NA, NA) 0.43 (0.13, 0.84) 0.45 (0.11, 0.87) 0.5 (0.15, 0.85) 0.44 (0.13, 0.84)
rate 0.112 (0.089, 0.143) 0.121 (0.088, 0.261) 0.119 (0.09, 0.22) 0.115 (0.085, 0.226) 0.124 (0.085, 0.252)
-+– graduation 0 313 264 332 333
futility 0 0 0 0 0
max_n 0 18 15 10 12
n 21 (14, 29) 4 (0, 13) 5 (2, 14) 10 (3, 22) 10 (3, 22)
n_unique 19 (13, 26) 4 (0, 12) 5 (2, 13) 9 (3, 21) 9 (3, 21)
post_p NA (NA, NA) 0.36 (0.14, 0.66) 0.34 (0.15, 0.66) 0.96 (0.63, 1) 0.95 (0.7, 1)
rate 0.114 (0.084, 0.151) 0.126 (0.072, 0.406) 0.125 (0.071, 0.34) 0.037 (0.02, 0.07) 0.038 (0.021, 0.067)
-+-+ graduation 0 328 288 337 338
futility 0 0 0 0 0
max_n 0 18 14 10 13
n 21 (15, 28) 4 (0, 13) 5 (1, 14) 10 (3, 23) 10 (3, 23)
n_unique 19 (13, 26) 3 (0, 12) 4 (1, 13) 9 (3, 22) 9 (3, 21)
post_p NA (NA, NA) 0.35 (0.17, 0.65) 0.32 (0.13, 0.67) 0.95 (0.69, 1) 0.96 (0.72, 1)
rate 0.112 (0.083, 0.151) 0.133 (0.073, 0.405) 0.128 (0.072, 0.365) 0.036 (0.018, 0.066) 0.036 (0.019, 0.066)
-++- graduation 0 152 149 282 293
futility 0 0 0 0 0
max_n 0 6 13 7 7
n 12 (8, 18) 3 (1, 9) 4 (1, 9) 6 (2, 14) 6 (2, 13)
n_unique 11 (7, 17) 3 (0, 8) 3 (1, 8) 6 (1, 13) 5 (1, 12)
post_p NA (NA, NA) 0.34 (0.16, 0.65) 0.36 (0.18, 0.63) 0.87 (0.5, 0.99) 0.86 (0.5, 0.99)
rate 0.114 (0.074, 0.175) 0.139 (0.068, 0.51) 0.133 (0.065, 0.474) 0.038 (0.016, 0.095) 0.036 (0.015, 0.1)
-+++ graduation 0 183 190 287 299
futility 0 0 0 0 0
max_n 0 6 13 7 9
n 12 (8, 18) 4 (1, 10) 4 (1, 9) 6 (1, 14) 6 (2, 14)
n_unique 11 (7, 16) 3 (1, 9) 3 (1, 8) 6 (1, 13) 5 (1, 13)
post_p NA (NA, NA) 0.36 (0.18, 0.65) 0.36 (0.17, 0.65) 0.88 (0.49, 0.99) 0.86 (0.49, 0.99)
rate 0.113 (0.076, 0.171) 0.131 (0.068, 0.426) 0.133 (0.064, 0.351) 0.038 (0.013, 0.099) 0.038 (0.013, 0.094)
+— graduation 0 27 3 16 10
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 20 (14, 27) 8 (2, 18) 11 (4, 21) 8 (2, 18) 8 (3, 17)
n_unique 18 (13, 24) 7 (2, 17) 10 (4, 20) 7 (2, 16) 7 (2, 15)
post_p NA (NA, NA) 0.42 (0.18, 0.84) 0.49 (0.16, 0.81) 0.47 (0.19, 0.85) 0.46 (0.18, 0.85)
rate 0.117 (0.085, 0.16) 0.129 (0.078, 0.316) 0.121 (0.082, 0.258) 0.124 (0.073, 0.294) 0.124 (0.072, 0.349)
+–+ graduation 0 84 73 46 46
futility 0 0 0 0 0
max_n 0 0 0 0 2
n 16 (11, 22) 7 (2, 16) 8 (3, 18) 6 (2, 13) 6 (2, 14)
n_unique 15 (10, 21) 6 (2, 15) 8 (3, 16) 5 (1, 12) 5 (2, 13)
post_p NA (NA, NA) 0.43 (0.18, 0.83) 0.44 (0.17, 0.86) 0.45 (0.2, 0.84) 0.48 (0.2, 0.81)
rate 0.116 (0.079, 0.166) 0.132 (0.075, 0.406) 0.127 (0.073, 0.268) 0.131 (0.071, 0.428) 0.125 (0.068, 0.37)
+-+- graduation 0 90 66 39 37
futility 0 0 0 0 0
max_n 0 6 14 8 8
n 16 (11, 22) 6 (1, 15) 8 (2, 16) 6 (2, 15) 6 (2, 14)
n_unique 15 (10, 20) 6 (1, 14) 7 (2, 15) 5 (1, 13) 5 (2, 13)
post_p NA (NA, NA) 0.44 (0.2, 0.84) 0.46 (0.18, 0.83) 0.46 (0.2, 0.82) 0.45 (0.19, 0.82)
rate 0.114 (0.08, 0.167) 0.128 (0.072, 0.361) 0.123 (0.074, 0.328) 0.125 (0.071, 0.388) 0.125 (0.073, 0.371)
+-++ graduation 0 127 121 63 66
futility 0 0 0 0 0
max_n 0 6 13 8 10
n 17 (11, 22) 6 (2, 15) 8 (3, 17) 6 (2, 14) 6 (2, 14)
n_unique 15 (10, 20) 5 (2, 14) 8 (2, 16) 5 (1, 13) 6 (2, 13)
post_p NA (NA, NA) 0.42 (0.19, 0.83) 0.47 (0.19, 0.84) 0.45 (0.2, 0.81) 0.49 (0.22, 0.84)
rate 0.113 (0.079, 0.167) 0.134 (0.072, 0.354) 0.122 (0.079, 0.311) 0.13 (0.075, 0.321) 0.118 (0.071, 0.337)
++– graduation 0 102 95 278 285
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 12 (8, 17) 3 (1, 9) 3 (1, 9) 6 (2, 14) 6 (2, 14)
n_unique 11 (7, 16) 3 (1, 8) 3 (1, 8) 6 (2, 13) 5 (2, 13)
post_p NA (NA, NA) 0.36 (0.17, 0.66) 0.36 (0.19, 0.68) 0.88 (0.51, 0.99) 0.87 (0.48, 0.99)
rate 0.115 (0.075, 0.178) 0.132 (0.062, 0.439) 0.13 (0.063, 0.445) 0.037 (0.014, 0.095) 0.037 (0.014, 0.1)
++-+ graduation 0 148 149 284 292
futility 0 0 0 0 0
max_n 0 0 0 0 2
n 12 (8, 17) 4 (1, 9) 4 (1, 8) 6 (2, 14) 6 (2, 14)
n_unique 11 (7, 16) 3 (1, 8) 3 (1, 8) 5 (2, 13) 6 (1, 13)
post_p NA (NA, NA) 0.35 (0.16, 0.67) 0.35 (0.18, 0.64) 0.86 (0.51, 0.98) 0.89 (0.57, 0.98)
rate 0.112 (0.073, 0.171) 0.131 (0.061, 0.39) 0.136 (0.063, 0.397) 0.037 (0.015, 0.093) 0.036 (0.014, 0.08)
+++- graduation 0 152 149 282 293
futility 0 0 0 0 0
max_n 0 6 13 7 7
n 12 (8, 17) 3 (1, 9) 4 (1, 9) 6 (2, 14) 6 (2, 14)
n_unique 11 (7, 16) 3 (1, 9) 3 (1, 8) 6 (1, 13) 5 (1, 13)
post_p NA (NA, NA) 0.36 (0.16, 0.65) 0.36 (0.18, 0.65) 0.85 (0.54, 0.98) 0.87 (0.52, 0.99)
rate 0.112 (0.074, 0.179) 0.129 (0.059, 0.333) 0.129 (0.062, 0.392) 0.038 (0.017, 0.085) 0.035 (0.014, 0.087)
++++ graduation 0 183 190 287 299
futility 0 0 0 0 0
max_n 0 6 13 7 9
n 12 (8, 18) 4 (1, 9) 3 (1, 9) 5 (2, 13) 6 (2, 14)
n_unique 11 (7, 16) 3 (1, 8) 3 (1, 9) 5 (1, 13) 5 (1, 13)
post_p NA (NA, NA) 0.38 (0.18, 0.69) 0.36 (0.17, 0.64) 0.86 (0.49, 0.98) 0.88 (0.47, 0.98)
rate 0.11 (0.071, 0.177) 0.122 (0.057, 0.386) 0.132 (0.061, 0.431) 0.038 (0.015, 0.097) 0.037 (0.015, 0.092)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 10 1 16 10
time_stop 5 (4, 6) 4 (4, 4) 7 (6, 24) 10 (7, 29)
n_trt 31 (29, 41) 25 (25, 25) 36 (28, 130) 50 (36, 118)
n_control 56 (51, 70) 43 (43, 43) 76 (60, 300) 108 (78, 348)
post_p 0.89 (0.86, 0.93) 0.88 (0.88, 0.88) 1 (0.97, 1) 1 (0.98, 1)
order 1 (1, 1) 1 (1, 1) 1 (1, 3.5) 1 (1, 6)
TP53- & AR- count 30 31 123 133
time_stop 9 (6, 15) 15 (11, 23) 15 (10, 30) 18 (10, 31)
n_trt 30 (26, 46) 36 (27, 56) 33 (26, 77) 41 (25, 93)
n_control 43 (27, 67) 63 (51, 111) 69 (41, 149) 79 (46, 148)
post_p 0.9 (0.86, 0.96) 0.92 (0.88, 0.96) 0.98 (0.91, 1) 0.99 (0.92, 1)
order 1 (1, 1.1) 1 (1, 3) 2 (1, 3) 2 (1, 3)
TP53+ count 5 2 24 27
time_stop 9 (8, 10) 8 (7, 10) 13 (9, 22) 16 (10, 32)
n_trt 29 (26, 30) 26 (25, 28) 33 (26, 60) 39 (27, 103)
n_control 38 (33, 44) 46 (38, 54) 64 (41, 109) 73 (41, 176)
post_p 0.95 (0.92, 0.97) 0.9 (0.9, 0.9) 1 (0.94, 1) 1 (0.94, 1)
order 1 (1, 1) 1.5 (1.1, 1.9) 2 (1, 3.7) 2 (1, 3.4)
DRD+ count 1 267 280
time_stop 21 (21, 21) 19 (11, 32) 18 (10, 32)
n_trt 25 (25, 25) 41 (26, 83) 42 (26, 86)
n_control 69 (69, 69) 57 (28, 100) 50 (27, 108)
post_p 0.98 (0.98, 0.98) 1 (0.98, 1) 1 (0.98, 1)
order 1 (1, 1) 2 (1, 4) 2 (1, 3)
TEfus+ count 2 4 31 41
time_stop 12 (11, 13) 10 (9, 11) 14 (11, 20) 15 (11, 28)
n_trt 30 (28, 32) 28 (25, 31) 28 (25, 42) 29 (25, 67)
n_control 50 (45, 54) 32 (31, 42) 51 (42, 79) 57 (40, 103)
post_p 0.96 (0.94, 0.97) 0.94 (0.88, 0.95) 1 (0.95, 1) 1 (0.97, 1)
order 1.5 (1.1, 1.9) 1 (1, 1) 2 (1, 3) 2 (1, 4)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 17 2
time_stop 5 (4, 35) 22 (21, 24)
n_trt 31 (25, 135) 98 (80, 116)
n_control 50 (37, 411) 258 (244, 271)
post_p 0.08 (0, 0.18) 0.01 (0.01, 0.02)
order 1 (1, 4.4) 4.5 (4.1, 4.9)
TP53- & AR- count 220 185 8 2
time_stop 16 (8, 30) 21 (13, 32) 17 (15, 24) 17 (15, 19)
n_trt 38 (26, 74) 35 (25, 80) 34 (28, 66) 44 (29, 58)
n_control 74 (32, 148) 101 (55, 162) 71 (60, 140) 89 (75, 103)
post_p 0.15 (0.05, 0.27) 0.16 (0.05, 0.27) 0.17 (0.12, 0.27) 0.16 (0.13, 0.19)
order 1 (1, 2) 2 (1, 3) 2 (1, 3.3) 2 (1.2, 2.8)
TP53+ count 63 63 1 1
time_stop 23 (11, 33) 19 (10, 32) 11 (11, 11) 10 (10, 10)
n_trt 41 (26, 77) 38 (26, 68) 26 (26, 26) 25 (25, 25)
n_control 113 (46, 178) 88 (38, 174) 40 (40, 40) 39 (39, 39)
post_p 0.08 (0.01, 0.24) 0.08 (0.01, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09)
order 2 (1, 4) 1 (1, 3) 1 (1, 1) 1 (1, 1)
DRD+ count 78 92
time_stop 29 (22, 35) 28 (21, 33)
n_trt 31 (25, 47) 29 (25, 50)
n_control 91 (66, 112) 90 (59, 117)
post_p 0.08 (0.02, 0.24) 0.1 (0.02, 0.22)
order 2 (1, 4) 2 (1, 4)
TEfus+ count 59 68
time_stop 23 (16, 32) 23 (13, 32)
n_trt 35 (26, 55) 40 (27, 64)
n_control 94 (60, 142) 91 (46, 140)
post_p 0.07 (0.01, 0.19) 0.06 (0.02, 0.21)
order 2 (1, 4) 2 (1, 4)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
time 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6)
n 15 (13, 16) 2 (1, 5) 8 (6, 10) 4 (1, 7) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 3) 2 (0, 3) 0 (0, 1) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1)
post_p 0.74 (0.64, 0.93) 0.6 (0.52, 0.65) 0.68 (0.6, 0.78) 0.7 (0.54, 0.75) NA (NA, NA) 0.53 (0.51, 0.59) 0.51 (0.51, 0.51) 0.54 (0.53, 0.55) 0.65 (0.57, 0.7) 0.64 (0.52, 0.74) 0.56 (0.55, 0.6) 0.57 (0.53, 0.6) NA (NA, NA) 0.51 (0.51, 0.51) 0.52 (0.52, 0.52) 0.51 (0.5, 0.53)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.045 (0.023, 0.073) 0.043 (0, 0.204) 0.039 (0, 0.08) 0 (0, 0.113) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.125) 0 (0, 0) 0 (0, 0.099) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Taxel_therapies count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
n 5 (5, 5) 0 (0, 0) 7 (7, 7) 4 (4, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 0 (0, 0) 2 (2, 2) 5 (5, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
post_p 0.76 (0.76, 0.76) NA (NA, NA) 0.53 (0.53, 0.53) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.76 (0.76, 0.76) NA (NA, NA) 0.51 (0.51, 0.51) 0.58 (0.58, 0.58) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.12 (0.12, 0.12) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.069 (0.069, 0.069) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Carboplatin count 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16
time 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24)
n 8 (2, 26) 2 (0, 6) 6 (3, 20) 3 (0, 14) 4 (0, 8) 3 (1, 6) 2 (0, 4) 1 (0, 4) 0 (0, 7) 2 (0, 6) 1 (0, 5) 1 (0, 7) 2 (0, 6) 3 (1, 6) 2 (1, 6) 2 (0, 4)
post_p 0.71 (0.6, 0.8) 0.64 (0.55, 0.71) 0.63 (0.53, 0.7) 0.59 (0.56, 0.7) 0.58 (0.5, 0.76) 0.64 (0.54, 0.8) 0.58 (0.53, 0.8) 0.58 (0.52, 0.71) 0.54 (0.51, 0.7) 0.59 (0.54, 0.74) 0.56 (0.51, 0.65) 0.61 (0.51, 0.74) 0.73 (0.55, 0.93) 0.61 (0.53, 0.82) 0.67 (0.53, 0.87) 0.63 (0.51, 0.71)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.036 (0, 0.094) 0 (0, 0.093) 0.074 (0, 0.099) 0.017 (0, 0.121) 0 (0, 0.049) 0 (0, 0.074) 0 (0, 0.04) 0 (0, 0.039) 0 (0, 0.119) 0 (0, 0.095) 0 (0, 0.091) 0 (0, 0.097) 0 (0, 0.028) 0 (0, 0.044) 0 (0, 0.042) 0 (0, 0.075)
Niraparib count 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
time 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29)
n 11 (4, 31) 2 (0, 4) 8 (5, 24) 4 (2, 13) 3 (0, 8) 6 (5, 7) 2 (1, 6) 3 (1, 4) 2 (0, 13) 0 (0, 4) 1 (1, 6) 2 (0, 3) 2 (1, 4) 3 (1, 5) 3 (2, 4) 2 (0, 4)
post_p 0.65 (0.5, 0.84) 0.7 (0.54, 0.81) 0.6 (0.55, 0.88) 0.68 (0.61, 0.86) 0.7 (0.56, 0.95) 0.73 (0.61, 0.96) 0.67 (0.6, 0.8) 0.64 (0.53, 0.77) 0.58 (0.51, 0.75) 0.57 (0.55, 0.6) 0.56 (0.5, 0.69) 0.56 (0.52, 0.8) 0.76 (0.56, 0.96) 0.61 (0.52, 0.89) 0.69 (0.59, 0.81) 0.7 (0.51, 0.89)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.09 (0.028, 0.116) 0.059 (0, 0.08) 0.097 (0, 0.127) 0.027 (0, 0.069) 0.025 (0, 0.033) 0.032 (0, 0.066) 0 (0, 0.053) 0.039 (0, 0.089) 0.046 (0, 0.099) 0.072 (0.026, 0.091) 0 (0, 0.134) 0 (0, 0.108) 0 (0, 0.022) 0.004 (0, 0.11) 0.025 (0, 0.069) 0 (0, 0.025)
TP53- & AR- Hormone_therapies count 30 30 30 30
time 9 (6, 15) 9 (6, 15) 9 (6, 15) 9 (6, 15)
n 24 (20, 34) 3 (2, 8) 1 (0, 5) 1 (0, 3)
post_p 0.89 (0.76, 0.96) 0.63 (0.52, 0.85) 0.62 (0.5, 0.74) 0.55 (0.51, 0.68)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.067 (0.035, 0.102) 0.056 (0, 0.121) 0 (0, 0.07) 0 (0, 0.071)
Taxel_therapies count 31 31 31 31
time 15 (11, 23) 15 (11, 23) 15 (11, 23) 15 (11, 23)
n 27 (16, 36) 5 (2, 13) 3 (0, 5) 2 (0, 5)
post_p 0.79 (0.73, 0.91) 0.72 (0.54, 0.91) 0.58 (0.51, 0.73) 0.58 (0.52, 0.79)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.076 (0.056, 0.096) 0.06 (0, 0.112) 0.048 (0, 0.097) 0.016 (0, 0.077)
Carboplatin count 123 123 123 123
time 15 (10, 30) 15 (10, 30) 15 (10, 30) 15 (10, 30)
n 19 (12, 48) 3 (1, 8) 6 (3, 15) 6 (3, 15)
post_p 0.78 (0.71, 0.91) 0.61 (0.51, 0.79) 0.79 (0.54, 0.98) 0.78 (0.56, 0.98)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.076 (0.04, 0.103) 0.068 (0, 0.114) 0.031 (0, 0.071) 0.03 (0, 0.066)
Niraparib count 133 133 133 133
time 18 (10, 31) 18 (10, 31) 18 (10, 31) 18 (10, 31)
n 20 (12, 61) 4 (1, 12) 6 (3, 14) 8 (3, 14)
post_p 0.76 (0.71, 0.93) 0.64 (0.51, 0.81) 0.87 (0.62, 0.98) 0.82 (0.67, 0.97)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.079 (0.047, 0.104) 0.074 (0, 0.126) 0.032 (0, 0.06) 0.031 (0, 0.06)
TP53+ Hormone_therapies count 5 5 5 5 5 5 5 5
time 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10)
n 16 (14, 19) 4 (3, 7) 2 (1, 3) 0 (0, 2) 2 (0, 3) 1 (0, 3) 1 (0, 2) 0 (0, 1)
post_p 0.86 (0.8, 0.94) 0.73 (0.66, 0.78) 0.58 (0.55, 0.61) 0.6 (0.55, 0.64) 0.6 (0.57, 0.76) 0.59 (0.54, 0.66) 0.54 (0.51, 0.57) 0.5 (0.5, 0.5)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.041 (0.022, 0.071) 0.048 (0, 0.063) 0 (0, 0) 0 (0, 0) 0 (0, 0.081) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Taxel_therapies count 2 2 2 2 2 2 2 2
time 8 (7, 10) 8 (7, 10) 8 (7, 10) 8 (7, 10) 8 (7, 10) 8 (7, 10) 8 (7, 10) 8 (7, 10)
n 6 (3, 10) 8 (5, 11) 1 (1, 1) 2 (0, 3) 3 (3, 3) 4 (3, 6) 0 (0, 1) 2 (1, 2)
post_p 0.63 (0.56, 0.71) 0.74 (0.73, 0.74) 0.51 (0.5, 0.52) 0.55 (0.55, 0.55) 0.6 (0.56, 0.63) 0.76 (0.63, 0.89) 0.51 (0.51, 0.51) 0.56 (0.55, 0.58)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.126 (0.098, 0.155) 0.054 (0.011, 0.097) 0 (0, 0) 0 (0, 0) 0.078 (0.061, 0.096) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Carboplatin count 24 24 24 24 24 24 24 24
time 13 (9, 22) 13 (9, 22) 13 (9, 22) 13 (9, 22) 13 (9, 22) 13 (9, 22) 13 (9, 22) 13 (9, 22)
n 10 (4, 17) 5 (1, 15) 4 (1, 7) 2 (1, 6) 3 (1, 5) 3 (0, 7) 3 (1, 8) 3 (1, 6)
post_p 0.79 (0.55, 0.89) 0.72 (0.54, 0.8) 0.66 (0.56, 0.86) 0.64 (0.54, 0.8) 0.63 (0.53, 0.78) 0.68 (0.56, 0.86) 0.65 (0.54, 0.87) 0.69 (0.56, 0.85)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.071 (0.008, 0.101) 0.076 (0, 0.11) 0 (0, 0.041) 0.037 (0, 0.06) 0.058 (0, 0.11) 0.057 (0, 0.11) 0 (0, 0.076) 0 (0, 0.079)
Niraparib count 27 27 27 27 27 27 27 27
time 16 (10, 32) 16 (10, 32) 16 (10, 32) 16 (10, 32) 16 (10, 32) 16 (10, 32) 16 (10, 32) 16 (10, 32)
n 16 (5, 34) 7 (3, 22) 4 (1, 7) 3 (0, 7) 3 (0, 11) 2 (1, 10) 4 (1, 11) 3 (2, 7)
post_p 0.75 (0.57, 0.91) 0.71 (0.57, 0.9) 0.78 (0.61, 0.91) 0.69 (0.51, 0.87) 0.7 (0.52, 0.89) 0.63 (0.54, 0.88) 0.74 (0.52, 0.95) 0.72 (0.54, 0.89)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.086 (0.055, 0.107) 0.08 (0.028, 0.112) 0.03 (0, 0.085) 0.032 (0, 0.078) 0.056 (0, 0.104) 0.067 (0, 0.111) 0.027 (0, 0.07) 0.014 (0, 0.065)
DRD+ Taxel_therapies count 1 1 1 1 1 1 1 1
time 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21)
n 4 (4, 4) 4 (4, 4) 4 (4, 4) 0 (0, 0) 1 (1, 1) 5 (5, 5) 3 (3, 3) 4 (4, 4)
post_p 0.67 (0.67, 0.67) 0.54 (0.54, 0.54) 0.5 (0.5, 0.5) NA (NA, NA) 0.5 (0.5, 0.5) 0.84 (0.84, 0.84) 0.87 (0.87, 0.87) 0.5 (0.5, 0.5)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.06 (0.06, 0.06) 0.114 (0.114, 0.114) 0.081 (0.081, 0.081) NA (NA, NA) 0 (0, 0) 0.039 (0.039, 0.039) 0 (0, 0) 0.07 (0.07, 0.07)
Carboplatin count 267 267 267 267 267 267 267 267
time 19 (11, 32) 19 (11, 32) 19 (11, 32) 19 (11, 32) 19 (11, 32) 19 (11, 32) 19 (11, 32) 19 (11, 32)
n 7 (3, 17) 8 (3, 16) 5 (2, 11) 5 (1, 11) 4 (1, 10) 4 (2, 11) 4 (1, 11) 4 (1, 11)
post_p 0.81 (0.6, 0.97) 0.81 (0.62, 0.97) 0.74 (0.56, 0.95) 0.74 (0.53, 0.94) 0.74 (0.54, 0.93) 0.75 (0.54, 0.94) 0.74 (0.55, 0.93) 0.74 (0.54, 0.95)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.035 (0, 0.064) 0.033 (0, 0.064) 0.028 (0, 0.068) 0.03 (0, 0.071) 0.029 (0, 0.074) 0.029 (0, 0.077) 0.031 (0, 0.068) 0.028 (0, 0.068)
Niraparib count 280 280 280 280 280 280 280 280
time 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32)
n 7 (3, 16) 8 (3, 17) 4 (1, 11) 4 (1, 10) 4 (1, 11) 4 (1, 11) 4 (2, 11) 4 (1, 11)
post_p 0.8 (0.59, 0.98) 0.82 (0.62, 0.98) 0.74 (0.54, 0.93) 0.72 (0.54, 0.93) 0.74 (0.54, 0.93) 0.76 (0.56, 0.94) 0.72 (0.53, 0.92) 0.75 (0.54, 0.95)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.032 (0, 0.07) 0.029 (0, 0.06) 0.028 (0, 0.071) 0.03 (0, 0.072) 0.028 (0, 0.07) 0.027 (0, 0.068) 0.029 (0, 0.072) 0.026 (0, 0.068)
TEfus+ Hormone_therapies count 2 2 2 2 2 2 2 2
time 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13)
n 6 (3, 8) 14 (10, 18) 1 (0, 2) 2 (0, 3) 2 (1, 4) 3 (2, 4) 2 (1, 2) 2 (0, 3)
post_p 0.75 (0.69, 0.81) 0.87 (0.83, 0.91) 0.69 (0.69, 0.69) 0.5 (0.5, 0.5) 0.66 (0.61, 0.71) 0.52 (0.51, 0.52) 0.54 (0.54, 0.54) 0.59 (0.59, 0.59)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.017 (0.003, 0.031) 0.055 (0.05, 0.061) 0 (0, 0) 0 (0, 0) 0.031 (0.006, 0.056) 0.025 (0.005, 0.045) 0 (0, 0) 0 (0, 0)
Taxel_therapies count 4 4 4 4 4 4 4 4
time 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11)
n 4 (4, 5) 8 (6, 13) 1 (0, 3) 1 (0, 2) 4 (3, 6) 3 (3, 4) 2 (1, 4) 2 (1, 2)
post_p 0.68 (0.65, 0.74) 0.81 (0.66, 0.95) 0.58 (0.52, 0.72) 0.52 (0.52, 0.53) 0.7 (0.56, 0.94) 0.7 (0.64, 0.75) 0.54 (0.51, 0.64) 0.53 (0.52, 0.61)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.054 (0.048, 0.096) 0.085 (0.063, 0.088) 0 (0, 0) 0 (0, 0) 0.043 (0, 0.086) 0.1 (0.067, 0.145) 0 (0, 0) 0 (0, 0)
Carboplatin count 31 31 31 31 31 31 31 31
time 14 (11, 20) 14 (11, 20) 14 (11, 20) 14 (11, 20) 14 (11, 20) 14 (11, 20) 14 (11, 20) 14 (11, 20)
n 3 (1, 5) 6 (3, 14) 5 (4, 8) 3 (2, 6) 2 (1, 5) 3 (1, 7) 3 (1, 5) 4 (1, 5)
post_p 0.61 (0.51, 0.73) 0.73 (0.53, 0.8) 0.77 (0.61, 0.92) 0.73 (0.55, 0.91) 0.61 (0.53, 0.85) 0.68 (0.54, 0.8) 0.68 (0.58, 0.82) 0.7 (0.53, 0.85)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.071 (0, 0.127) 0.075 (0.04, 0.1) 0.03 (0, 0.061) 0 (0, 0.064) 0.036 (0, 0.115) 0.045 (0, 0.117) 0.031 (0, 0.087) 0.008 (0, 0.076)
Niraparib count 41 41 41 41 41 41 41 41
time 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28)
n 3 (1, 7) 7 (3, 18) 7 (4, 12) 3 (2, 7) 3 (1, 7) 3 (0, 7) 4 (1, 8) 3 (1, 8)
post_p 0.64 (0.53, 0.84) 0.75 (0.6, 0.86) 0.83 (0.72, 0.94) 0.72 (0.54, 0.89) 0.6 (0.52, 0.84) 0.67 (0.55, 0.81) 0.71 (0.52, 0.88) 0.7 (0.55, 0.92)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.059 (0, 0.098) 0.066 (0, 0.097) 0.019 (0, 0.054) 0.023 (0, 0.069) 0.033 (0, 0.12) 0.065 (0, 0.113) 0.029 (0, 0.086) 0.014 (0, 0.07)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17
time 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35)
n 15 (11, 32) 2 (1, 6) 7 (4, 29) 2 (1, 9) 0 (0, 4) 0 (0, 7) 0 (0, 3) 0 (0, 2) 2 (0, 12) 2 (0, 5) 1 (0, 6) 2 (0, 6) 0 (0, 3) 0 (0, 4) 0 (0, 3) 0 (0, 2)
post_p 0.27 (0.05, 0.45) 0.32 (0.23, 0.41) 0.33 (0.16, 0.39) 0.34 (0.26, 0.43) 0.33 (0.17, 0.5) 0.39 (0.29, 0.47) 0.18 (0.16, 0.37) 0.36 (0.31, 0.46) 0.36 (0.19, 0.48) 0.36 (0.25, 0.45) 0.33 (0.22, 0.48) 0.41 (0.37, 0.49) 0.39 (0.26, 0.47) 0.33 (0.27, 0.47) 0.4 (0.13, 0.46) 0.36 (0.33, 0.41)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.134 (0.078, 0.274) 0.18 (0.041, 0.346) 0.177 (0.117, 0.27) 0.228 (0.054, 0.6) 0.152 (0, 0.594) 0.108 (0.097, 0.839) 0.192 (0.06, 0.826) 0.974 (0.082, 5.57) 0.081 (0, 0.225) 0.158 (0, 0.272) 0.155 (0, 0.766) 0.19 (0.041, 0.258) 0.151 (0.076, 0.539) 0.108 (0, 0.205) 0.142 (0, 0.294) 0.33 (0.124, 27.05)
Taxel_therapies count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24)
n 27 (21, 33) 6 (4, 7) 8 (6, 9) 9 (4, 14) 3 (2, 4) 10 (5, 14) 3 (2, 4) 3 (2, 4) 6 (5, 6) 4 (4, 4) 2 (2, 3) 6 (5, 8) 4 (2, 5) 2 (1, 4) 5 (3, 7) 2 (1, 2)
post_p 0.38 (0.35, 0.41) 0.31 (0.29, 0.33) 0.22 (0.22, 0.22) 0.3 (0.19, 0.41) 0.28 (0.27, 0.29) 0.24 (0.2, 0.29) 0.23 (0.2, 0.26) 0.38 (0.37, 0.4) 0.3 (0.15, 0.45) 0.45 (0.44, 0.45) 0.25 (0.17, 0.32) 0.39 (0.38, 0.41) 0.37 (0.3, 0.44) 0.18 (0.08, 0.28) 0.3 (0.22, 0.38) 0.19 (0.06, 0.33)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.13 (0.123, 0.138) 0.183 (0.156, 0.209) 0.226 (0.199, 0.253) 0.276 (0.167, 0.386) 0.263 (0.176, 0.349) 0.176 (0.143, 0.209) 0.223 (0.202, 0.245) 0.173 (0.123, 0.223) 0.223 (0.142, 0.305) 0.215 (0.207, 0.223) 0.285 (0.26, 0.309) 0.144 (0.127, 0.162) 0.069 (0.065, 0.074) 0.224 (0.174, 0.275) 0.802 (0.26, 1.345) 0.239 (0.236, 0.242)
TP53- & AR- Hormone_therapies count 220 220 220 220
time 16 (8, 30) 16 (8, 30) 16 (8, 30) 16 (8, 30)
n 24 (16, 56) 5 (2, 11) 3 (0, 8) 3 (0, 7)
post_p 0.32 (0.11, 0.47) 0.38 (0.18, 0.49) 0.35 (0.17, 0.48) 0.36 (0.17, 0.48)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.128 (0.107, 0.173) 0.153 (0.089, 0.349) 0.139 (0.071, 0.538) 0.141 (0.069, 0.58)
Taxel_therapies count 185 185 185 185
time 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32)
n 21 (10, 60) 6 (3, 13) 4 (1, 10) 4 (1, 9)
post_p 0.34 (0.1, 0.47) 0.34 (0.15, 0.47) 0.32 (0.16, 0.47) 0.32 (0.15, 0.47)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.128 (0.106, 0.193) 0.155 (0.107, 0.345) 0.151 (0.083, 0.55) 0.142 (0.085, 0.428)
Carboplatin count 8 8 8 8
time 17 (15, 24) 17 (15, 24) 17 (15, 24) 17 (15, 24)
n 24 (16, 42) 3 (1, 12) 4 (1, 7) 4 (2, 12)
post_p 0.28 (0.12, 0.44) 0.39 (0.17, 0.44) 0.29 (0.12, 0.43) 0.41 (0.32, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.14 (0.117, 0.189) 0.164 (0.107, 0.225) 0.212 (0.085, 0.539) 0.118 (0.055, 0.288)
Niraparib count 2 2 2 2
time 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19)
n 32 (18, 47) 2 (2, 3) 4 (3, 4) 5 (4, 6)
post_p 0.34 (0.27, 0.41) 0.21 (0.16, 0.26) 0.3 (0.2, 0.39) 0.4 (0.39, 0.4)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.138 (0.121, 0.155) 0.573 (0.374, 0.773) 0.231 (0.144, 0.318) 0.118 (0.084, 0.153)
TP53+ Hormone_therapies count 63 63 63 63 63 63 63 63
time 23 (11, 33) 23 (11, 33) 23 (11, 33) 23 (11, 33) 23 (11, 33) 23 (11, 33) 23 (11, 33) 23 (11, 33)
n 14 (8, 32) 8 (3, 22) 2 (1, 5) 2 (0, 7) 4 (1, 10) 3 (1, 7) 2 (0, 6) 2 (1, 6)
post_p 0.3 (0.12, 0.47) 0.36 (0.12, 0.48) 0.35 (0.2, 0.47) 0.36 (0.21, 0.47) 0.36 (0.22, 0.47) 0.36 (0.22, 0.48) 0.37 (0.2, 0.45) 0.34 (0.17, 0.46)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.142 (0.111, 0.217) 0.139 (0.097, 0.316) 0.172 (0.066, 0.67) 0.153 (0.082, 0.595) 0.171 (0.097, 0.83) 0.176 (0.1, 0.546) 0.175 (0.075, 0.397) 0.181 (0.09, 0.828)
Taxel_therapies count 63 63 63 63 63 63 63 63
time 19 (10, 32) 19 (10, 32) 19 (10, 32) 19 (10, 32) 19 (10, 32) 19 (10, 32) 19 (10, 32) 19 (10, 32)
n 9 (5, 25) 11 (5, 19) 2 (0, 4) 2 (0, 5) 4 (2, 9) 4 (1, 9) 2 (0, 6) 2 (0, 5)
post_p 0.28 (0.16, 0.45) 0.37 (0.17, 0.48) 0.36 (0.22, 0.47) 0.33 (0.15, 0.48) 0.36 (0.17, 0.46) 0.35 (0.19, 0.45) 0.35 (0.22, 0.48) 0.39 (0.2, 0.5)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.146 (0.103, 0.254) 0.143 (0.103, 0.241) 0.162 (0.069, 0.646) 0.171 (0.078, 0.503) 0.162 (0.11, 0.422) 0.177 (0.102, 0.42) 0.159 (0.069, 0.531) 0.141 (0.062, 0.552)
Carboplatin count 1 1 1 1 1 1 1 1
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 12 (12, 12) 5 (5, 5) 0 (0, 0) 2 (2, 2) 1 (1, 1) 1 (1, 1) 3 (3, 3) 2 (2, 2)
post_p 0.36 (0.36, 0.36) 0.47 (0.47, 0.47) NA (NA, NA) 0.38 (0.38, 0.38) 0.34 (0.34, 0.34) 0.34 (0.34, 0.34) 0.5 (0.5, 0.5) 0.36 (0.36, 0.36)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.17 (0.17, 0.17) 0.092 (0.092, 0.092) NA (NA, NA) 0.165 (0.165, 0.165) 0.301 (0.301, 0.301) 0.565 (0.565, 0.565) 0.078 (0.078, 0.078) 0.592 (0.592, 0.592)
Niraparib count 1 1 1 1 1 1 1 1
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 6 (6, 6) 2 (2, 2) 4 (4, 4) 3 (3, 3) 3 (3, 3) 1 (1, 1) 3 (3, 3) 3 (3, 3)
post_p 0.21 (0.21, 0.21) 0.28 (0.28, 0.28) 0.44 (0.44, 0.44) 0.33 (0.33, 0.33) 0.4 (0.4, 0.4) 0.21 (0.21, 0.21) 0.48 (0.48, 0.48) 0.46 (0.46, 0.46)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.195 (0.195, 0.195) 0.365 (0.365, 0.365) 0.077 (0.077, 0.077) 0.139 (0.139, 0.139) 0.277 (0.277, 0.277) 0.36 (0.36, 0.36) 0 (0, 0) 0.086 (0.086, 0.086)
DRD+ Hormone_therapies count 78 78 78 78 78 78 78 78
time 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35)
n 4 (2, 10) 5 (1, 12) 3 (1, 8) 3 (1, 7) 3 (1, 7) 4 (1, 6) 4 (1, 7) 3 (1, 7)
post_p 0.33 (0.12, 0.48) 0.31 (0.17, 0.45) 0.3 (0.16, 0.45) 0.32 (0.18, 0.45) 0.33 (0.18, 0.46) 0.31 (0.16, 0.47) 0.32 (0.15, 0.46) 0.35 (0.19, 0.44)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.158 (0.091, 0.488) 0.125 (0.087, 0.35) 0.172 (0.083, 0.679) 0.152 (0.089, 0.578) 0.147 (0.092, 0.599) 0.173 (0.101, 0.493) 0.15 (0.093, 0.422) 0.148 (0.093, 0.524)
Taxel_therapies count 92 92 92 92 92 92 92 92
time 28 (21, 33) 28 (21, 33) 28 (21, 33) 28 (21, 33) 28 (21, 33) 28 (21, 33) 28 (21, 33) 28 (21, 33)
n 5 (2, 11) 5 (2, 11) 3 (1, 7) 3 (1, 7) 3 (1, 6) 3 (1, 8) 3 (1, 7) 3 (1, 8)
post_p 0.31 (0.17, 0.47) 0.32 (0.13, 0.48) 0.34 (0.2, 0.46) 0.33 (0.15, 0.47) 0.33 (0.17, 0.46) 0.34 (0.16, 0.45) 0.35 (0.19, 0.48) 0.3 (0.14, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.133 (0.089, 0.302) 0.143 (0.083, 0.37) 0.16 (0.085, 0.473) 0.144 (0.094, 0.51) 0.167 (0.09, 1.203) 0.139 (0.085, 0.447) 0.157 (0.083, 0.424) 0.153 (0.096, 0.646)
TEfus+ Hormone_therapies count 59 59 59 59 59 59 59 59
time 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32)
n 4 (2, 9) 9 (4, 22) 4 (0, 9) 3 (0, 6) 3 (1, 9) 3 (1, 7) 2 (1, 5) 3 (1, 6)
post_p 0.31 (0.12, 0.46) 0.34 (0.14, 0.47) 0.32 (0.16, 0.47) 0.37 (0.22, 0.46) 0.31 (0.18, 0.46) 0.34 (0.2, 0.46) 0.33 (0.21, 0.47) 0.35 (0.18, 0.48)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.186 (0.112, 0.525) 0.156 (0.111, 0.265) 0.13 (0.087, 0.658) 0.139 (0.076, 0.586) 0.188 (0.108, 0.682) 0.179 (0.107, 0.386) 0.162 (0.086, 0.545) 0.148 (0.077, 0.501)
Taxel_therapies count 68 68 68 68 68 68 68 68
time 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32)
n 5 (2, 11) 10 (6, 26) 3 (1, 7) 2 (1, 5) 5 (2, 10) 5 (2, 8) 2 (1, 7) 3 (0, 7)
post_p 0.33 (0.13, 0.47) 0.29 (0.1, 0.47) 0.31 (0.16, 0.46) 0.32 (0.18, 0.48) 0.34 (0.19, 0.49) 0.35 (0.17, 0.48) 0.35 (0.16, 0.48) 0.39 (0.18, 0.48)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.165 (0.112, 0.418) 0.142 (0.102, 0.298) 0.165 (0.082, 0.497) 0.163 (0.076, 0.363) 0.16 (0.095, 0.326) 0.167 (0.099, 0.443) 0.155 (0.079, 0.453) 0.146 (0.063, 0.393)